Nature's Life MSM Tri-Slfate Joint Ease™ Product:

• MSM Tri-Sulfate

Every movement of your body involves your joints. Joints are protected and supported by cartilage, a dense, shock absorbing connective tissue; and protective synovial fluid that lubricates joint movement.

Stress on joints can damage cartilage and trigger the natural inflammatory response, leading to swelling and significant discomfort. The natural inflammatory response is the body’s attempt to minimize the adverse affects of stress and trauma. This mechanism is highly effective, but often excessive. An overabundance of synovial fluid in joints results in swelling, discomfort and limited movement. Supplements to relieve joint discomfort should therefore focus on protecting and building cartilage and maintaining normal synovial fluid levels.

Sulfur compounds, such as those found in Nature’s Life MSM Tri-Sulfate Joint Ease™, are critical for maintaining and protecting normal cartilage structure and inhibiting the natural inflammatory response with few, if any, side effects.* Drugs that reduce inflammation are effective, but even the relatively "safe" ones like aspirin can induce gastritis or ulcers.

Nature’s Life MSM Tri-Sulfate Joint Ease™ Supplement

• Contains MSM, chondroitin sulfate and glucosamine sulfate

• Reduces discomfort and tenderness in joints*

• Helps maintain normal cartilage growth and function*

• Attracts cushioning fluids to the cartilage matrix*

• Helps slow the action of degrading enzymes in joints*

• Naturally occurring source of dietary sulfur.

Sulfur is the eighth most abundant element in all living organisms and is found in especially high concentrations in the connective tissues of joints, where it is essential for maintaining normal function. Supplementing the body’s sulfur intake can have significant potential for relieving joint discomfort.*1,2

MSM

MSM (Methylsulfonyl Methane) is a naturally occurring form of sulfur.3 MSM’s effectiveness is thought to be a result of its action as a sulfur donor to repair damaged connective tissues.*4 An odorless, white crystalline substance, MSM is an oxidative product of its parent compound dimethyl sulfoxide (DMSO).4,5 Several well-established studies have shown conclusively that DMSO is highly effective in relieving joint discomfort and inhibiting the natural inflammatory response.*6,7,8,9 MSM appears to provide the same benefits as DMSO, yet MSM is retained in the body longer and does not produce sulfur’s strong, unpleasant odor.*6

Glucosamine Sulfate

Glucosamine sulfate is a mucopolysaccharide found in cartilage and synovial fluid. A mucopolysaccharide is a compound of glucose (a sugar) and glutamine (an amino acid). Glucosamine bonds to water to create pockets of moisture that absorb shock and maintain resilience.* Glucosamine stimulates and supports the production of cartilage cells, or chondrocytes.* Contributing to glucosamine’s effectiveness is its 98% absorption rate.*10 Once absorbed, glucosamine sulfate is distributed primarily to joint tissues.*10

Chondroitin sulfate

Chondroitin sulfate is a mucopolysaccharide that acts as a structural component in connective tissue.*11 Just as glucosamine sulfate helps attract moisture to cartilage by bonding to water, chondroitin sulfate enhances this effect through its negative electrical charge.11 Chondrocytes, in addition to creating new mucopolysaccharides, also secrete enzymes that degrade old mucopolysaccharides. Chondroitin sulfate inhibits the breakdown of cartilage, protecting the existing tissue.*11,12,13,14

References:

1. Murav’ev IuV, Venikova MS, Pleskovskaia GN, et al. Effect of dimethyl sulfoxide and dimethyl sulfone on a destructive process in the joints of mice with spontaneous arthritis. Patol Fiziol Eksp Ter. 1991;2:37-9.

2. Lawrence RM. Methylsulfonylmethane (MSM): a double-blind study of its use in degenerative arthritis. Int J of Anti-Aging Med.1998;1:50.

3. Richmond VL. Incorporation of methylsulfonyl methane sulfur into guinea pig serum proteins. Life Sci 1986;39:263-68.

4. Jacob S, Herschler R. Biological Actions and Medical Applications of Dimethyl Sulfoxide, Introductory Remarks. Ann NY Acad Sci 1983;411:xiii-xvii.

5. Hucker HB, Ahmad PM, Miller EA, et al. Metabolism of Dimethyl Sulfoxide to Dimethyl Sulfone in the Rat and Man. Nature 1966;209:619-620.

6. Percy EC, Carson JD. The use of DMSO in tennis elbow and rotator cuff tendonitis: a double-blind study. Med Sci Sports Exerc 1981;13:215-19.

7. Kneer W, Kuhnau S, Bias P, et al. Dimethylsulfoxide (DMSO) gel in treatment of acute tendopathies. A multicenter, placebo-controlled, randomized study. Fortschr Med 1994;112:142-6.

8. Swanson BN. Medical use of dimethyl sulfoxide (DMSO). Rev Clin Basic Pharm 1985;5:1-33.

9. Eberhardt R, Zqingers T, Hoffman R. DMSO in patients with active gonarthrosis. A double-blind placebo-controlled phase III study. Fortschr Med 1995;113:446-50.

10. Setnikar I, Giacchetti C, Zanolo G. Pharmacokinetics of glucosamine in the dog and man. Arzneim Forsch 1986;36:729.

11. Tapadinhas MJ, Rivera C, Bignamini AA. Oral glucosamine sulfate in the management of arthrosis: report on a multi-centre open investigation in Portugal. Pharmatherapeutica 1982;3:157.

12. Conte A, Volpi n, Palmieri L, et al. Biomedical and pharmacokinetic aspects of oral treatment with chondroitin sulfate. Arzneim-Forsch 1995;45:918-25.

13. Pipitone V, Amabanelli U, Cervini C, et al. A multicenter, triple-blind study to evaluate galactosaminoglucuronoglycan sulfate vs. placebo in patients with femorotibial gonarthritis. Curr Ther Res 1992;52:608-38.

14. Pipitone VR. Chondroprotection with chondroitin sulfate. Drugs Exper Clin Res 1991